Human calicivirus
			Typing tool

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Complete norovirus genomes

PQ209096	GII.4 Sydney
	GII.P31

Length: 3,288 | 3 CDS

ORF1: 1..854
ORF2: 835..2457
ORF3: 2457..3263
LOCUS       PQ209096                3288 bp    RNA     linear   VRL 01-JAN-2025
DEFINITION  Norovirus GII isolate Hu/GII.4 Sydney[P31]/Clackamas0391/2014/USA
            nonstructural polyprotein, RdRp region, (ORF1) gene, partial cds;
            and VP1 (ORF2) and VP2 (ORF3) genes, complete cds.
ACCESSION   PQ209096
VERSION     PQ209096.1
KEYWORDS    .
SOURCE      Norovirus GII
  ORGANISM  Norovirus GII
            Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
            Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE   1  (bases 1 to 3288)
  AUTHORS   Barclay,L., Montmayeur,A.M., Cannon,J.L., Mallory,M.L., Reyes,Y.I.,
            Lindesmith,L., Wall,H., Baric,R.S., Vinje,J. and Chhabra,P.
  TITLE     Norovirus GII.4 evolution in the United States since emergence of
            GII.4 Sydney
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 3288)
  AUTHORS   Tsaknaridis,L.J., Barclay,L., Montmayeur,A.M., Vinje,J. and
            Chhabra,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-AUG-2024) Viral Gastroenteritis Branch, Centers for
            Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA
            30329, USA
COMMENT     ##Assembly-Data-START##
            Assembly Method       :: Geneious v. v. 11.1.2; SPAdes v. v. 3.6
            Sequencing Technology :: Sanger dideoxy sequencing; Illumina
            ##Assembly-Data-END##
FEATURES             Location/Qualifiers
     source          1..3288
                     /organism="Norovirus GII"
                     /mol_type="genomic RNA"
                     /isolate="Hu/GII.4 Sydney[P31]/Clackamas0391/2014/USA"
                     /isolation_source="stool"
                     /host="Homo sapiens"
                     /db_xref="taxon:122929"
                     /geo_loc_name="USA"
                     /collection_date="12-Jun-2014"
                     /note="genotype: GII.4 Sydney[P31]"
     gene            <1..854
                     /gene="ORF1"
     CDS             <1..854
                     /gene="ORF1"
                     /codon_start=3
                     /product="nonstructural polyprotein"
                     /protein_id="XEO40399.1"
                     /translation="IFEKHSRYRYHYDADYSRWDSTQQRDVLAAALEIMVKFSPEPHL
                     AQIVAEDLLSPSVMDVGDFQISISEGLPSGVPCTSQWNSIAHWLLTLCALSEVTDLSP
                     DIIQANSLFSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTRPDKTEGPLVISEDLDG
                     LTFLRRTVTRDPAGWFGKLEQSSILRQMYWTRGPNHEDPFETMIPHSQRPIQLMSLLG
                     EAALHGPAFYSKISKLVIAELKEGGMDFYVPRQEPMFRWMRFSDLSTWEGDRNLAPSF
                     VNEDGVE"
     mat_peptide     <1..851
                     /gene="ORF1"
                     /product="RdRp"
     gene            835..2457
                     /gene="ORF2"
     CDS             835..2457
                     /gene="ORF2"
                     /note="major capsid protein"
                     /codon_start=1
                     /product="VP1"
                     /protein_id="XEO40400.1"
                     /translation="MKMASSDANPSDGSAASLVPEVNNEVMALEPVVGAAIAAPVAGQ
                     QNVIDPWIRNNFVQAPGGEFTVSPRNAPGEILWSAPLGPDLNPYLSHLARMYNGYAGG
                     FEVQVILAGNAFTAGKVIFAAVPPNFPTEGLSPSQVTMFPHIVVDVRQLEPVLIPLPD
                     VRNNFYHYNQSNDPTIKLIAMLYTPLRANNAGDDVFTVSCRVLTRPSPDFDFIFLVPP
                     TVESRTKPFSVPVLTVEEMTNSRFPIPLEKLFTGPSSAFVVQPQNGRCTTDGVLLGTT
                     QLSPVNVCTFRGDVTHITGSHNYTMNLASQNWNNYDPTEEIPAPLGTPDFVGKIQGVL
                     TQTTRTDGSTRGHKATVYTGSADFAPKLGRVQFETDTNHDFEANQNTKFTPVGVIQDG
                     GTTHRNEPQQWVLPSYSGRNTHNVHLAPAVAPTFPGEQLLFFRSTMPGCSGYPNMDLD
                     CLLPQEWVQYFYQEAAPAQSDVALLRFVNPDTGRVLFECKLHKSGYVTVAHTGQHDLV
                     IPPNGYFRFDSWVNQFYTLAPMGNGTGRRRAV"
     gene            2457..3263
                     /gene="ORF3"
     CDS             2457..3263
                     /gene="ORF3"
                     /note="minor structural protein; small basic protein"
                     /codon_start=1
                     /product="VP2"
                     /protein_id="XEO40401.1"
                     /translation="MAGAFFAGLASDVLGSGLGSLINAGAGAINQKVEFENNRKLQQA
                     SFQFSSNLQQASFQHDKEMLQAQIEATKKLQQEMMKVKQAMLLEGGFSETDAARGAIN
                     APMTKSLDWSGTRYWAPDARTTTYNAGRFSTPQPSGALPGRANLRDTVPARGSSSKSS
                     NSSTVTSVYSNQTTSTRLGSTAGSGTSVSSFPSTARTRSWVEDQSRNLSPFIRGAHNI
                     SFVTPPSSRSSSQGTVSTVPKEILDSWTGAFNTRRQPLFAHIRKRGESRA"
ORIGIN      
        1 tcatatttga gaagcactcc agatatagat atcactatga tgctgattat tcccggtggg
       61 actcaacaca acaaagggat gttctagcag cagcactaga aatcatggtt aagttctctc
      121 cagaaccaca cctggcccag atagttgcag aagacctcct ttcccctagc gtaatggatg
      181 taggtgactt tcaaatatca ataagtgagg gtctcccctc tggggtacct tgcacctccc
      241 agtggaattc catcgcccac tggctcctca ctctttgtgc actctctgaa gtcacggacc
      301 tgtcccctga cattattcag gccaactccc ttttctcttt ctatggtgat gatgagattg
      361 taagcacaga cataaagttg gacccagaga agctgacagc aaaactcaag gagtacgggc
      421 tgaaaccaac ccgccccgac aaaactgaag gaccccttgt tatctctgaa gacctggatg
      481 gcctgacatt cctccggaga actgtgaccc gtgatccagc tggctggttt ggaaaattgg
      541 aacaaagttc aattctcagg caaatgtact ggaccagggg tcccaaccat gaagatccat
      601 ttgaaacaat gataccacac tcccaaagac ccatacaatt gatgtccctg ctgggcgagg
      661 ctgcactcca cggcccggca ttctatagca aaattagcaa attagtcatt gcagagttga
      721 aggaaggtgg catggatttt tacgtgccca gacaagagcc aatgttcaga tggatgagat
      781 tctcagacct gagcacgtgg gagggcgatc gcaatctggc tcccagtttt gtgaatgaag
      841 atggcgtcga gtgacgccaa cccatctgat gggtccgcag ccagcctcgt cccagaggtc
      901 aacaatgagg ttatggctct ggagcccgtt gttggtgccg ccattgcggc acctgtagcg
      961 ggccaacaga atgtaattga cccctggatt agaaataatt ttgtacaagc ccctggtgga
     1021 gagtttacag tatcccctag aaacgctcca ggtgaaatac tatggagcgc gcccttgggc
     1081 cctgatctaa atccctacct atcccatttg gccagaatgt acaatggtta tgcaggtggt
     1141 tttgaagtgc aggtaattct cgcggggaat gcgttcaccg ccgggaaggt catatttgca
     1201 gcagtcccac caaattttcc aactgaaggc ttgagcccca gccaggtcac tatgttcccc
     1261 catatagtag tagatgttag gcaattagaa cctgtgttga ttcccttacc cgatgttagg
     1321 aataatttct atcattacaa tcaatcaaat gaccccacca ttaagttgat agcaatgttg
     1381 tatacaccac ttagggctaa taacgctggg gacgatgtct tcacagtctc ttgccgagtt
     1441 ctcacgagac catcccccga ttttgatttc atatttctag tgccacccac agttgagtca
     1501 aggactaaac cattctctgt cccagtttta actgttgagg agatgaccaa ttcaagattc
     1561 cccattcctt tggaaaagtt gttcacgggt cccagtagtg ccttcgttgt ccaaccacaa
     1621 aacggcaggt gcacgactga tggcgtgctc ctaggcacca cccaactgtc tcctgtcaac
     1681 gtctgcacct tcaggggaga tgtcacccat atcacaggta gtcataacta cacaatgaat
     1741 ttggcttctc aaaattggaa caattatgac ccaacagaag aaatcccagc ccctctggga
     1801 actccagatt ttgtggggaa gattcaaggc gtgctcaccc aaaccacaag gacagatggc
     1861 tcaacacgcg gccacaaagc tacagtgtac actgggagcg ccgactttgc tccaaaactg
     1921 ggtagagttc aatttgaaac tgacacaaac catgattttg aagctaacca aaacacaaag
     1981 ttcaccccag tcggcgtcat ccaagatggt ggcaccaccc accgaaatga accccaacag
     2041 tgggtgctcc caagttactc aggcagaaat actcataatg tgcatctggc ccccgctgta
     2101 gcccccactt ttccgggtga gcaacttctc ttcttcagat ccaccatgcc cggatgcagc
     2161 gggtacccca acatggattt ggactgtctg ctcccccagg aatgggtgca gtacttctac
     2221 caagaggcag ccccagcaca atctgatgtg gctctgctga gatttgtgaa tccagacaca
     2281 ggtagggttt tgtttgagtg taagcttcat aaatcaggct atgttacagt ggctcacact
     2341 ggccaacatg atttggttat ccccccaaat ggttatttta ggtttgattc ctgggtcaac
     2401 cagttttaca cgcttgcccc catgggaaat ggaacggggc gtagacgtgc agtataatgg
     2461 ctggagcttt ctttgctgga ttggcatctg atgtccttgg ctctggactt ggttccctta
     2521 tcaatgctgg ggctggggcc atcaaccaaa aagttgagtt tgaaaataac agaaaattgc
     2581 aacaagcatc cttccaattt agcagcaatc tacaacaggc ttcctttcaa catgataaag
     2641 agatgctcca agcgcaaatt gaggccacca aaaagctaca acaggaaatg atgaaagtta
     2701 agcaggcaat gctcctagag ggtggattct ctgagacaga tgcagcccgc ggggcaatca
     2761 acgcccccat gacaaaatct ttggactgga gcgggacaag gtactgggct cctgatgcta
     2821 ggactacaac atacaatgca ggccgctttt ccacccctca accatcgggg gcactgccag
     2881 gaagagctaa tcttagggat actgtccctg ctcggggttc ctccagcaaa tcttctaact
     2941 cttccactgt cacttctgtg tactcaaatc aaactacttc aacgagactt ggttctacag
     3001 ctggttctgg taccagtgtc tcgagcttcc cgtcaactgc aaggactagg agctgggttg
     3061 aggatcaaag taggaatttg tcacctttca ttaggggggc ccacaacata tcgtttgtca
     3121 ccccaccatc tagcagatcc tctagccaag gcacagtctc aaccgtgcct aaagagattt
     3181 tggactcctg gactggcgct ttcaacacgc gcaggcagcc actcttcgct cacattcgta
     3241 agcgagggga gtcacgggcg taatgtgaaa agacaaaatt gattatct
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