Typing tool
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Typing tool
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Complete norovirus genomes
| PQ195927 | GII.4 Sydney | |
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| GII.P16 |
ORF1: 1..5100
ORF2: 5081..6703
ORF3: 6703..7509
LOCUS PQ195927 7524 bp RNA linear VRL 01-JAN-2025
DEFINITION Norovirus GII isolate Hu/GII.4 Sydney[P16]/Mercer0110/2022/USA
nonstructural polyprotein (ORF1), VP1 (ORF2), and VP2 (ORF3) genes,
complete cds.
ACCESSION PQ195927
VERSION PQ195927.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7524)
AUTHORS Barclay,L., Montmayeur,A.M., Cannon,J.L., Mallory,M.L., Reyes,Y.I.,
Lindesmith,L., Wall,H., Baric,R.S., Vinje,J. and Chhabra,P.
TITLE Norovirus GII.4 evolution in the United States since emergence of
GII.4 Sydney
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7524)
AUTHORS Brandt,E., Barclay,L., Montmayeur,A.M., Vinje,J. and Chhabra,P.
TITLE Direct Submission
JOURNAL Submitted (16-AUG-2024) Viral Gastroenteritis Branch, Centers for
Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA
30329, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: Geneious v. v. 11.1.2; SPAdes v. v. 3.6
Sequencing Technology :: Sanger dideoxy sequencing; Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7524
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Hu/GII.4 Sydney[P16]/Mercer0110/2022/USA"
/isolation_source="stool"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="USA"
/collection_date="21-Apr-2022"
/note="genotype: GII.4 Sydney[P16]"
gene 1..5100
/gene="ORF1"
CDS 1..5100
/gene="ORF1"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="XEJ39093.1"
/translation="MKMASNDASAAVARNSNNDKEKSSGEGLFTNMSSTLKKALGARP
KQPAPRDEPQQPPRPPTPELVKRIPPPPPNGEAEGEPVIRYEVKGGISGLPELTTVPQ
PDVANTAFSVPPLSLRENREAKEPLTGAILEMWDGEIYHYGLYVEKGLVLGVHKPPAA
ISMARVELTPLSLYWRVVYTPQYLISPETLRRLSGEVFPYTAFDNNCYAFCCWVLDLN
DSWLSRRMVQRTTGFFRPYQEWNRKPLPTMDESKIKKVANIFLCSLSTLFTRPIKDLI
GKIKPLNILNILATCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYELQGP
EDLAVELVPVVMGGIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWF
FPKKEEANELAMVRAIEDAVLDLEAIENNHMTTLLKDKDSLATYMKTLDMEEEKARRL
STKSASPDIVGTINALLARIAAARSLVHRAKEELSSRMRPVVVMISGKPGIGKTHLAR
EVARKVASTLTGDQRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRIQELAD
TCPLTLNCDRIENKGKVFDSEVIIITTNLANPAPLDYVNFEACSRRIDFLVYAEAPEV
EKAKRDFPGQPDMWKDAFKPDFSHIKLQLAPQGGFDKNGNTPHGKGVMKTLTTGSLIA
RASGLLHERMDEFELQGPTITTFNFDRNRITAFRQLAAENKYGLVDTMKVGNQLKGVK
TMEELKQAIRNVTIKRCRIIYGGSTYDLESDGKGKILVEKVKNTSVQTNNELAGALHH
LKHARIRYYVKCVQEAVYSIIQIAGAAFVTTRIARRMNIQELWSKPQLDQNETETKEE
APKPEDDEFIISSKDIKEEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNG
KYSIEEYLQDRDRYYEELAIAKATEEDFCEEEEIKIRQRIFRPTRKQRKEERATLGLI
TGSEIRRRNPDDFKPKGKLWADDNRSVDYNEKLDFEAPPSIWSRIVSFGSGWGFWVSP
SLFITSTHVIPAGITEAFGIPIKQIQIHKSGEFCRFRFPKPIRPDVAGMILEEGAPEG
TVATVLIKRPTGELMPLAARMGTHATMKIQGRMVGGQMGMLLTGSNAKGMDLGTTPGD
CGCPYIYKRGNDYIVIGVHTAAARGGNTVICATQGSEGEATLEGGDDKGTYCGAPILG
PGGAPKLSTKTKFWRSSNTPLPPGTYEPAYLGGRDPRVKGGPSLQQVMRDQLKPFTEP
RGKPPRPNVLEAAKQTIINVLEQTLDPPQKWTYTQACASLDKTTSSGHPHHVRKNEFW
NGETFTGKLADQASKANLMFEEGKHMTPVYTAALKDELVKTEKIYGKIKKRLLWGSDL
STMIRCARSFGGLMDEMKAHCISLPVRVGMNMNEDGPIIFEKHSRYKYHYDADYSRWD
STQQRAVLAAALEIMVRFSAEPQLAQVVAEDLLAPSVVDVGDFKITINEGLPSGVPCT
SQWNSIAHWLLTLCALSEVTKLSPDIIQANSMFSFYGDDEIVSTDIKLDPEQLTAKLK
EYGLKPTRPDKTEGPLIISEDLNGLTFLRRTVTRDPAGWFGKLDQSSILRQMYWTRGP
NHEDPNETMIPHSQRPIQLMALLGEASLHGPSFYSRISKLVITELKEGGMDFYVPRQE
PMFRWMRFSDLSTWEGDRNLAPNFVNEDGVE"
mat_peptide 1..996
/gene="ORF1"
/product="p48"
mat_peptide 997..2094
/gene="ORF1"
/product="NTPase"
mat_peptide 2095..2625
/gene="ORF1"
/product="p22"
mat_peptide 2626..3024
/gene="ORF1"
/product="VPg"
mat_peptide 3025..3567
/gene="ORF1"
/product="Pro"
mat_peptide 3568..5097
/gene="ORF1"
/product="RdRp"
gene 5081..6703
/gene="ORF2"
CDS 5081..6703
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="XEJ39094.1"
/translation="MKMASSDANPSDGSAANLVPEVNNEVMALEPVVGAAIAAPVAGQ
QNVIDPWIRTNFVQAPGGEFTVSPRNAPGEILWSAPLGPDLNPYLSHLARMYNGYAGG
FEVQVILAGNAFTAGKIIFAAVPPNFPTEGLSPSQVTMFPHIIVDVRQLEPVLIPLPD
VRNNFYHYNQSNDSTIKLIAMLYTPLRANNAGDDVFTVSCRVLTRPSPDFDFIFLVPP
TVESRTKPFSVPVLTVEEMTNSRFPIPLEKLFTGPSSAFVVQPQNGRCTTDGVLLGTT
QLSPVNICTFRGDVTHITGSRNYTMNLASQNWNNYDPTEEIPAPLGTPDFVGKIQGML
TQTTRTDGSTRGHKATVYTGSADFAPKLGRVQFETDTDHDFEANQNTKFTPVGVIQDG
STTHRNEPQQWVLPSYSGRNTHNVHLAPAVAPTFPGEQLLFFRSTMPGCSGYPNMDLD
CLLPQEWVQYFYQEAAPAQSDVALLRFVNPDTGRVLFECKLHKSGYVTVAHTGQHDLV
IPPNGYFRFDSWVNQFYTLAPMGNGTGRRRAV"
gene 6703..7509
/gene="ORF3"
CDS 6703..7509
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="XEJ39095.1"
/translation="MAGAFFAGLASDVLGSGLGSLINAGAGAINQKVEFENNRKLQQA
SFQFSSNLQQASFQHDKEMLQAQIEATKKLQQEMMKVKQAMLLEGGFSETDAARGALN
APMTKVLDWSGTRYWAPDARTTTYNTGRFSIPQPSGTLPGRANLRDAAPARGPSNKSS
NSSIATSVYSNQTTSTRLGSTAGSGTSVSSLPSTARTRGWVEDQNRNLSPFMKGAHNI
SFVTPPSSRSSSQGTVSTVPKEILDSWTGAFNTHRQPLFAHIRKRGESRV"
ORIGIN
1 atgaagatgg cgtctaacga cgcttccgct gccgttgctc gcaacagcaa caacgacaag
61 gaaaaatctt caggtgaagg cttattcaca aatatgtcct ccaccttaaa gaaagccctc
121 ggggctaggc ccaaacagcc tgccccgaga gacgaaccac aacagcctcc aagaccaccg
181 actcccgagt tggtcaagag gataccccct cccccaccta atggcgaagc agaaggagag
241 ccagtcatta ggtatgaggt caagggtgga atctctggcc tgcccgagct cacaacagtc
301 ccccaaccgg acgtggccaa cacagcgttc agtgttccac cactgagctt gagagaaaac
361 agggaggcca aggaaccgct aacaggggcg atattagaga tgtgggatgg agagatatac
421 cactatggcc tgtacgtgga gaaaggttta gtgttgggtg tgcacaaacc gcctgcagcc
481 ataagcatgg caagggtgga gctgacgcca ctgtcactgt actggcgtgt ggtgtacact
541 ccccaatacc tcatctcccc tgaaactctc aggaggctca gcggagaggt gttcccttac
601 accgctttcg acaacaactg ctatgctttt tgctgctggg tgttagacct caatgactca
661 tggcttagca ggaggatggt gcaaagaaca acgggcttct tcagacctta ccaagagtgg
721 aacagaaagc ccctgcctac catggatgaa tcaaaaatta agaaagtagc aaatatattc
781 ctatgttcat tgtccacatt attcaccaga cccataaaag atctcatagg aaaaattaaa
841 ccattaaaca tattaaacat cctggcaacg tgtgactgga cgtttgccgg aatagtggag
901 tctctgatat tacttgctga actcttcgga gttttctgga cgcccccaga tgtgtctgct
961 atgatcgctc ccttactcgg ggactacgag ttgcaaggac cagaagacct cgccgttgaa
1021 ctcgtacctg tggtaatggg agggattggt ttggttctgg gattcaccaa agagaaaatt
1081 ggcaaaatgt tgtcctcagc agcatcaaca ctcagggctt gcaaagatct tggtgcctat
1141 ggcttagaga tactcaagct ggtcatgaag tggttcttcc caaagaaaga agaggccaat
1201 gagctagcca tggtgagggc catagaggat gccgtactag atcttgaggc aatagaaaac
1261 aaccacatga caaccctgtt gaaggataaa gacagcttag caacatacat gaaaacattg
1321 gacatggagg aggagaaagc caggaggtta tccacaaagt ctgcgtcccc tgacatagtt
1381 gggacaatca atgccttgct ggctcgaata gcagcggcca ggtcattagt tcatagggcc
1441 aaggaagagt tatctagcag gatgagacca gtagttgtta tgatatctgg taaaccagga
1501 ataggcaaaa ctcatctggc cagggaagtg gcaagaaagg tggcatccac cctcacaggg
1561 gaccaaagag tcggactcat accaagaaac ggtgtggacc attgggatgc atataaaggt
1621 gagagagtcg tgctgtggga cgactatggc atgagtaacc ccatccatga tgctcttcgc
1681 atacaagaat tggctgatac gtgtcccctt accttaaact gtgacagaat tgaaaacaag
1741 ggaaaagttt ttgacagtga agtcataata attacaacaa accttgccaa cccagcccca
1801 cttgattatg tcaactttga ggcctgttcc aggagaattg acttcctggt atacgctgag
1861 gcaccagagg tagaaaaggc aaaacgagac tttcctggtc agccagacat gtggaaggac
1921 gccttcaaac cggacttctc acacatcaag ctacagcttg cacctcaggg cggctttgac
1981 aagaacggca acaccccaca tgggaaagga gtgatgaaga ccctcactac cggttctttg
2041 attgcccgtg catcaggcct actgcatgag aggatggatg agtttgagct ccaaggaccc
2101 acaatcacca ccttcaattt cgaccggaac agaatcacag cattcagaca actggctgca
2161 gaaaacaagt atgggttggt ggatactatg aaagttggca atcaactaaa aggagtgaaa
2221 accatggaag aactcaaaca agcaatcaga aatgtgacca tcaagaggtg tcggatcatc
2281 tacggtggct ccacgtatga ccttgaatct gatggcaagg gcaaaatttt ggtggagaag
2341 gtcaagaaca cctctgtaca gaccaacaac gagttggccg gggctctgca ccaccttaaa
2401 catgcccgga tcaggtacta tgtcaaatgt gtgcaagaag cagtctactc cataatacaa
2461 attgccggcg ctgcgtttgt caccacgcgc attgcacgcc gcatgaacat acaagaactc
2521 tggtcgaaac cacaattaga tcaaaatgaa acagagacta aggaggaggc ccccaaacca
2581 gaagatgacg agttcatcat atcttctaag gacatcaagg aggaaggaaa gaagggcaaa
2641 aacaagactg gccgtggcaa gaagcacact gcattttcca gcaagggctt gagcgatgag
2701 gagtatgacg agtacaagag gataagagaa gagagaaatg ggaagtactc tatagaggag
2761 tatcttcaag acagagacag atactatgag gagcttgcca ttgccaaggc cacggaagaa
2821 gacttctgtg aagaggagga gattaaaatc cgtcagagaa ttttccgtcc caccaggaaa
2881 caaaggaagg aagagagggc cacattagga ctgataacag gttcagaaat caggagaaga
2941 aaccctgatg acttcaagcc caaagggaag ctgtgggccg atgacaacag aagtgttgac
3001 tataatgaga aactggattt tgaggccccc ccaagcatat ggtctaggat tgtgagcttt
3061 ggttctggct ggggcttctg ggtatcacca agcctgttca taacatcaac tcatgtaatc
3121 cccgcaggca taacagaagc atttggaatc cccatcaaac aaattcagat ccacaaatca
3181 ggtgaatttt gccgattcag attcccaaaa ccaattagac cagatgtggc aggaatgatc
3241 ttggaagaag gtgcgcctga aggcaccgtg gcaactgtgc tcatcaaacg tcccaccgga
3301 gagctcatgc cccttgcagc cagaatggga acacacgcaa ccatgaaaat tcaaggccgc
3361 atggttggcg gacagatggg tatgttgctc actggatcaa atgccaaagg aatggatttg
3421 ggaacaactc ctggtgactg tggctgtcct tacatctaca aaaggggcaa tgattacata
3481 gtcattgggg tgcacactgc agcagcccgt ggtggaaaca ccgtcatctg tgccacacag
3541 gggagtgagg gtgaggcaac tcttgagggt ggagatgaca aaggaacata ctgtggggca
3601 cccatcctag gccctggggg tgcaccaaag ctgagcacca aaaccaaatt ttggaggtca
3661 tcgaatacgc cccttccacc agggacgtat gagcctgctt acctcggtgg ccgtgatccg
3721 cgtgttaagg gtgggccttc cttgcagcag gtaatgagag accagttgaa gccattcact
3781 gaacccaggg gcaaacctcc aagaccaaat gtattggaag cagccaaaca aaccattatc
3841 aatgtcctcg aacaaaccct ggatcctcca caaaaatgga catacacaca ggcgtgtgcc
3901 tcacttgaca aaaccacttc cagcgggcat ccccatcatg tccgaaagaa tgaattctgg
3961 aatggtgaga cattcactgg caaattagca gaccaagcat caaaagcaaa cctaatgttt
4021 gaggaaggga aacacatgac accagtgtac acagcagctc tcaaagacga gctagtcaag
4081 actgagaaga tttatggaaa gatcaagaag agactgctct ggggttctga cttgtccacc
4141 atgatccggt gcgctaggtc atttggtggg ctcatggacg agatgaaggc acactgcata
4201 tcactcccag tgcgagttgg tatgaatatg aatgaagatg gcccaataat atttgagaaa
4261 cattccagat acaaatacca ctatgatgca gactactccc gctgggactc aacccaacag
4321 agggcagtac tagccgcagc cctggaaatc atggtcagat tctctgcaga accacaattg
4381 gcacaagtag tcgctgagga tctgctggcc cctagcgtag tggatgtggg agactttaaa
4441 atcacaataa atgaagggct cccgtctggt gtgccatgca cttctcaatg gaactctatc
4501 gcacactggc tgctgactct ctgcgccttg tccgaagtca ccaaactgtc ccctgacatt
4561 atacaagcaa attccatgtt ctcattttac ggtgatgacg agattgtcag caccgacata
4621 aaattggacc ctgaacagtt aaccgctaag ttgaaggagt acggcctaaa accaacccgc
4681 ccagacaaga ccgagggacc cctgatcatc agtgaagatt tgaacggact cactttcctc
4741 cgaaggacgg tgacccgtga cccagctggc tggtttggga aactggacca aagttcaatt
4801 ttgaggcaga tgtactggac tagaggacca aatcatgaag atcccaatga gacaatgata
4861 ccccattctc aaagacccat acagcttatg gcattgcttg gtgaagcctc tcttcacgga
4921 ccctctttct acagtagaat cagtaaactg gtcataactg aactcaaaga aggcgggatg
4981 gacttttatg tgccaagaca ggaacccatg ttcaggtgga tgaggttttc tgacttgagc
5041 acgtgggagg gcgatcgcaa tctggctccc aattttgtga atgaagatgg cgtcgagtga
5101 cgccaaccca tctgatgggt ccgcagccaa cctcgtacca gaggtcaaca atgaggttat
5161 ggctttggag cccgttgttg gtgccgctat tgcggcacct gtagcgggcc aacaaaatgt
5221 aattgacccc tggattagaa ctaattttgt acaagcccct ggtggggagt ttacagtatc
5281 ccctagaaac gctccaggtg aaatactatg gagtgcgccc ctgggtcctg acctaaatcc
5341 ctatttatcc catttggcca gaatgtacaa tggttatgca ggtggttttg aagtgcaggt
5401 aattctcgcg gggaacgcgt tcaccgctgg gaagattata tttgcagcag tcccaccaaa
5461 tttcccaact gaaggcttaa gtcctagcca ggttactatg ttcccccata taatagtaga
5521 tgttaggcaa ttagaacctg tgttgattcc cttacccgat gttaggaata atttttatca
5581 ttacaatcag tcaaatgatt ctactattaa gttgatagca atgttgtaca caccacttag
5641 ggctaataat gctggggatg atgttttcac agtttcgtgc cgagttctca cgagaccatc
5701 ccccgatttt gattttatat ttttagtgcc acccacagtt gagtcaagaa ctaaaccatt
5761 ctccgtccca gttttaactg ttgaggagat gaccaattca agattcccca tccctttgga
5821 aaaattgttc acaggcccca gtagtgcctt tgttgttcaa ccacaaaacg gcaggtgtac
5881 aactgatggc gtgctcctag gcaccaccca actctctcct gtcaacatct gcactttcag
5941 aggggatgtc acccatatca caggtagtcg caactacaca atgaatttgg cttctcaaaa
6001 ttggaacaat tatgacccaa cagaagaaat cccagcccct ctgggaaccc cagattttgt
6061 agggaagatt caaggcatgc tcacccaaac cacaaggaca gatggttcaa cacgcggcca
6121 caaagctaca gtgtacactg ggagcgccga ctttgctcca aaactgggta gagttcaatt
6181 tgaaactgac acagatcatg actttgaagc taatcaaaac acaaagttca ccccagtcgg
6241 tgtcatccaa gatggtagca ccactcatcg aaatgaaccc caacagtggg tgctcccaag
6301 ttactcaggc agaaacactc acaatgtaca tctggccccc gctgtagccc ccacctttcc
6361 gggtgagcag cttctcttct tcaggtccac catgcccgga tgcagcgggt accccaacat
6421 ggatttggac tgtctgctcc cccaggaatg ggtgcagtac ttctaccaag aggcagcccc
6481 agcacaatct gatgtggctc tgttaagatt tgtgaatcca gacacaggta gggtcttgtt
6541 tgagtgcaag cttcacaaat cagggtatgt cacggtggct cacactggcc aacatgattt
6601 ggttatcccc cccaatggct actttaggtt tgattcctgg gtcaatcagt tctacacgct
6661 cgcccccatg ggaaatggaa cggggcgtag acgtgcagta taatggctgg agctttcttt
6721 gctggattgg catctgatgt ccttggctct gggcttggtt ctctcatcaa tgccggtgct
6781 ggggccatca accaaaaagt tgagttcgaa aataatagaa aattgcaaca agcatccttc
6841 caatttagca gcaatctgca acaggcttcc ttccaacatg ataaagagat gctccaagca
6901 caaattgagg ccaccaaaaa gctgcaacag gaaatgatga aagttaagca ggcaatgctc
6961 ctagagggtg gattctctga gacagatgca gcccgcgggg cactcaacgc ccccatgaca
7021 aaagttttgg actggagcgg gacaaggtac tgggctcccg atgctaggac tacaacatac
7081 aacacaggcc gcttttccat tcctcaacca tcggggacac tgccaggaag agctaatctt
7141 agggatgctg cccctgctcg gggaccctcc aataaatctt ctaactcttc tattgccact
7201 tctgtgtatt caaatcaaac tacttcaacg agacttggtt ctacagctgg ttctggaacc
7261 agtgtctcga gcctcccgtc aactgcaagg actaggggct gggttgagga tcaaaatagg
7321 aatttgtcac ctttcatgaa gggggcccac aacatatcat ttgtcacccc accatctagc
7381 agatcctcta gccaaggcac agtctcaacc gtgcctaaag agattttgga ctcctggact
7441 ggcgctttca acacgcacag gcagcctctc ttcgcccaca ttcgtaagcg aggggagtca
7501 cgggtgtaat gtgaaaagac aaaa
//