Typing tool
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Typing tool
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Complete norovirus genomes
| NC_001959 | GI.1 | |
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|---|---|---|---|
| GI.P1 |
ORF1: 5..5374
ORF2: 5358..6950
ORF3: 6950..7588
LOCUS NC_001959 7654 bp ss-RNA linear VRL 13-AUG-2018
DEFINITION Norovirus GI, complete genome.
ACCESSION NC_001959
VERSION NC_001959.2
DBLINK BioProject: PRJNA485481
KEYWORDS RefSeq.
SOURCE Norovirus GI
ORGANISM Norovirus GI
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7654)
AUTHORS Fernandez-Vega,V., Sosnovtsev,S.V., Belliot,G., King,A.D.,
Mitra,T., Gorbalenya,A. and Green,K.Y.
TITLE Norwalk virus N-terminal nonstructural protein is associated with
disassembly of the Golgi complex in transfected cells
JOURNAL J. Virol. 78 (9), 4827-4837 (2004)
PUBMED 15078964
REFERENCE 2 (bases 1 to 7654)
AUTHORS Liu,B.L., Viljoen,G.J., Clarke,I.N. and Lambden,P.R.
TITLE Identification of further proteolytic cleavage sites in the
Southampton calicivirus polyprotein by expression of the viral
protease in E. coli
JOURNAL J. Gen. Virol. 80 (Pt 2), 291-296 (1999)
PUBMED 10073687
REFERENCE 3 (bases 1 to 7654)
AUTHORS Liu,B., Clarke,I.N. and Lambden,P.R.
TITLE Polyprotein processing in Southampton virus: identification of
3C-like protease cleavage sites by in vitro mutagenesis
JOURNAL J. Virol. 70 (4), 2605-2610 (1996)
PUBMED 8642693
REFERENCE 4 (bases 1 to 12)
AUTHORS Hardy,M.E. and Estes,M.K.
TITLE Completion of the Norwalk virus genome sequence
JOURNAL Virus Genes 12 (3), 287-290 (1996)
PUBMED 8883366
REFERENCE 5 (bases 13 to 7654)
AUTHORS Jiang,X., Wang,M., Wang,K. and Estes,M.K.
TITLE Sequence and genomic organization of Norwalk virus
JOURNAL Virology 195 (1), 51-61 (1993)
PUBMED 8391187
REFERENCE 6 (bases 1 to 7654)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (01-AUG-2000) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 7 (bases 1 to 12)
AUTHORS Hardy,M.E.
TITLE Direct Submission
JOURNAL Submitted (07-NOV-1995) Michele E. Hardy, Molecular Virology,
Baylor College of Medicine, Houston, TX 77006, USA
REFERENCE 8 (bases 13 to 7654)
AUTHORS Estes,M.K.
TITLE Direct Submission
JOURNAL Submitted (09-AUG-1993) M.K. Estes, Molecular Virology, Baylor
College of Medicine, Houston, TX 77006, USA
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from M87661.
On Jun 1, 2006 this sequence version replaced NC_001959.1.
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..7654
/organism="Norovirus GI"
/mol_type="genomic RNA"
/db_xref="taxon:122928"
5'UTR 1..4
gene 5..5374
/gene="ORF1"
/locus_tag="NoVGI_gp1"
/old_locus_tag="NVgp1"
/db_xref="GeneID:1491970"
CDS 5..5374
/gene="ORF1"
/locus_tag="NoVGI_gp1"
/old_locus_tag="NVgp1"
/note="The mature peptides were added by the NCBI staff
following publications Liu et all (1996, 1999), that
(tentatively) determined processing map by site-directed
mutagenesis or by direct sequencing of the cleavage
products for closely related Southampton virus (a
Norwalk-like virus); ORF1; sequence homologies to 2C
helicase, 3C protease, and 3D RNA-dependent RNA polymerase
of picornavirus"
/codon_start=1
/product="nonstructural polyprotein"
/protein_id="NP_056820.1"
/db_xref="GeneID:1491970"
/translation="MMMASKDVVPTAASSENANNNSSIKSRLLARLKGSGGATSPPNS
IKITNQDMALGLIGQVPAPKATSVDVPKQQRDRPPRTVAEVQQNLRWTERPQDQNVKT
WDELDHTTKQQILDEHAEWFDAGGLGPSTLPTSHERYTHENDEGHQVKWSAREGVDLG
ISGLTTVSGPEWNMCPLPPVDQRSTTPATEPTIGDMIEFYEGHIYHYAIYIGQGKTVG
VHSPQAAFSITRITIQPISAWWRVCYVPQPKQRLTYDQLKELENEPWPYAAVTNNCFE
FCCQVMCLEDTWLQRKLISSGRFYHPTQDWSRDTPEFQQDSKLEMVRDAVLAAINGLV
SRPFKDLLGKLKPLNVLNLLSNCDWTFMGVVEMVVLLLELFGIFWNPPDVSNFIASLL
PDFHLQGPEDLARDLVPIVLGGIGLAIGFTRDKVSKMMKNAVDGLRAATQLGQYGLEI
FSLLKKYFFGGDQTEKTLKDIESAVIDMEVLSSTSVTQLVRDKQSARAYMAILDNEEE
KARKLSVRNADPHVVSSTNALISRISMARAALAKAQAEMTSRMRPVVIMMCGPPGIGK
TKAAEHLAKRLANEIRPGGKVGLVPREAVDHWDGYHGEEVMLWDDYGMTKIQEDCNKL
QAIADSAPLTLNCDRIENKGMQFVSDAIVITTNAPGPAPVDFVNLGPVCRRVDFLVYC
TAPEVEHTRKVSPGDTTALKDCFKPDFSHLKMELAPQGGFDNQGNTPFGKGVMKPTTI
NRLLIQAVALTMERQDEFQLQGPTYDFDTDRVAAFTRMARANGLGLISMASLGKKLRS
VTTIEGLKNALSGYKISKCSIQWQSRVYIIESDGASVQIKEDKQALTPLQQTINTASL
AITRLKAARAVAYASCFQSAITTILQMAGSALVINRAVKRMFGTRTAAMALEGPGKEH
NCRVHKAKEAGKGPIGHDDMVERFGLCETEEEESEDQIQMVPSDAVPEGKNKGKTKKG
RGRKNNYNAFSRRGLSDEEYEEYKKIREEKNGNYSIQEYLEDRQRYEEELAEVQAGGD
GGIGETEMEIRHRVFYKSKSKKHQQEQRRQLGLVTGSDIRKRKPIDWTPPKNEWADDD
REVDYNEKINFEAPPTLWSRVTKFGSGWGFWVSPTVFITTTHVVPTGVKEFFGEPLSS
IAIHQAGEFTQFRFSKKMRPDLTGMVLEEGCPEGTVCSVLIKRDSGELLPLAVRMGAI
ASMRIQGRLVHGQSGMLLTGANAKGMDLGTIPGDCGAPYVHKRGNDWVVCGVHAAATK
SGNTVVCAVQAGEGETALEGGDKGHYAGHEIVRYGSGPALSTKTKFWRSSPEPLPPGV
YEPAYLGGKDPRVQNGPSLQQVLRDQLKPFADPRGRMPEPGLLEAAVETVTSMLEQTM
DTPSPWSYADACQSLDKTTSSGYPHHKRKNDDWNGTTFVGELGEQAAHANNMYENAKH
MKPIYTAALKDELVKPEKIYQKVKKRLLWGADLGTVVRAARAFGPFCDAIKSHVIKLP
IKVGMNTIEDGPLIYAEHAKYKNHFDADYTAWDSTQNRQIMTESFSIMSRLTASPELA
EVVAQDLLAPSEMDVGDYVIRVKEGLPSGFPCTSQVNSINHWIITLCALSEATGLSPD
VVQSMSYFSFYGDDEIVSTDIDFDPARLTQILKEYGLKPTRPDKTEGPIQVRKNVDGL
VFLRRTISRDAAGFQGRLDRASIERQIFWTRGPNHSDPSETLVPHTQRKIQLISLLGE
ASLHGEKFYRKISSKVIHEIKTGGLEMYVPGWQAMFRWMRFHDLGLWTGDRDLLPEFV
NDDGV"
mat_peptide 5..1198
/gene="ORF1"
/locus_tag="NoVGI_gp1"
/old_locus_tag="NVgp1"
/product="p48"
/note="N-terminal leader p48; 2A2-2B-like membrane
protein; distant homolog of H-rev107-like parechovirus
2a2, a putative regulator of cell proliferation; the
c-terminal membrane-binding portion contributes to the
Golgi disassembly and, therefore, functionally similar to
the picornavirus 2B protein"
/protein_id="NP_786945.1"
mat_peptide 1199..2287
/gene="ORF1"
/locus_tag="NoVGI_gp1"
/old_locus_tag="NVgp1"
/product="NTPase"
/note="2C-L; probable ortholog of the 2C protein of
picornaviruses; the calicivirus NTPase was found in
membranous replication complexes"
/protein_id="NP_786946.1"
mat_peptide 2288..2890
/gene="ORF1"
/locus_tag="NoVGI_gp1"
/old_locus_tag="NVgp1"
/product="p22"
/note="3A-L; located in the polyprotein between NTPase and
VPg; second most variable region of the calicivirus
polyprotein; the FCV ortholog was detected in membranous
replication complexes"
/protein_id="NP_786947.1"
mat_peptide 2891..3304
/gene="ORF1"
/locus_tag="NoVGI_gp1"
/old_locus_tag="NVgp1"
/product="VPg"
/note="For Southampton calicivirus, both N-terminal and
C-terminal cleavage sites have been confirmed by direct
sequencing. In caliciviruses, VPg can also exist in the
form of precursor with the upstream protein which is
thought to function as a membrane anchor"
/protein_id="NP_786948.1"
mat_peptide 3305..3847
/gene="ORF1"
/locus_tag="NoVGI_gp1"
/old_locus_tag="NVgp1"
/product="Pro"
/note="Chymotrypsin-like cysteine proteinase; For
Southampton calicivirus, both N-terminal and C-terminal
cleavage sites have been confirmed by direct sequencing.
The FCV proteinase (Pro) can exist in the form of a stable
Pro-Pol precursor"
/protein_id="NP_786949.1"
mat_peptide 3848..5371
/gene="ORF1"
/locus_tag="NoVGI_gp1"
/old_locus_tag="NVgp1"
/product="RdRp"
/note="the FCV polymerase (Pol) can exist in the form of a
stable Pro-Pol precursor; RNA-dependent RNA polymerase"
/protein_id="NP_786950.1"
gene 5358..6950
/gene="ORF2"
/locus_tag="NoVGI_gp2"
/old_locus_tag="NVgp2"
/db_xref="GeneID:1491972"
CDS 5358..6950
/gene="ORF2"
/locus_tag="NoVGI_gp2"
/old_locus_tag="NVgp2"
/note="ORF2; 58kd capsid protein; major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="NP_056821.2"
/db_xref="GeneID:1491972"
/translation="MMMASKDATSSVDGASGAGQLVPEVNASDPLAMDPVAGSSTAVA
TAGQVNPIDPWIINNFVQAPQGEFTISPNNTPGDVLFDLSLGPHLNPFLLHLSQMYNG
WVGNMRVRIMLAGNAFTAGKIIVSCIPPGFGSHNLTIAQATLFPHVIADVRTLDPIEV
PLEDVRNVLFHNNDRNQQTMRLVCMLYTPLRTGGGTGDSFVVAGRVMTCPSPDFNFLF
LVPPTVEQKTRPFTLPNLPLSSLSNSRAPLPISSMGISPDNVQSVQFQNGRCTLDGRL
VGTTPVSLSHVAKIRGTSNGTVINLTELDGTPFHPFEGPAPIGFPDLGGCDWHINMTQ
FGHSSQTQYDVDTTPDTFVPHLGSIQANGIGSGNYVGVLSWISPPSHPSGSQVDLWKI
PNYGSSITEATHLAPSVYPPGFGEVLVFFMSKMPGPGAYNLPCLLPQEYISHLASEQA
PTVGEAALLHYVDPDTGRNLGEFKAYPDGFLTCVPNGASSGPQQLPINGVFVFVSWVS
RFYQLKPVGTASSARGRLGLRR"
gene 6950..7588
/gene="ORF3"
/locus_tag="NoVGI_gp3"
/old_locus_tag="NVgp3"
/db_xref="GeneID:1491971"
CDS 6950..7588
/gene="ORF3"
/locus_tag="NoVGI_gp3"
/old_locus_tag="NVgp3"
/note="ORF3; minor structural protein; small basic
protein"
/codon_start=1
/product="VP2"
/protein_id="NP_056822.1"
/db_xref="GeneID:1491971"
/translation="MAQAIIGAIAASTAGSALGAGIQVGGEAALQSQRYQQNLQLQEN
SFKHDREMIGYQVEASNQLLAKNLATRYSLLRAGGLTSADAARSVAGAPVTRIVDWNG
VRVSAPESSATTLRSGGFMSVPIPFASKQKQVQSSGISNPNYSPSSISRTTSWVESQN
SSRFGNLSPYHAEALNTVWLTPPGSTASSTLSSVPRGYFNTDRLPLFANNRR"
3'UTR 7589..7654
ORIGIN
1 gtgaatgatg atggcgtcaa aagacgtcgt tcctactgct gctagcagtg aaaatgctaa
61 caacaatagt agtattaagt ctcgtctatt ggcgagactc aagggttcag gtggggctac
121 gtccccaccc aactcgataa agataaccaa ccaagatatg gctctggggc tgattggaca
181 ggtcccagcg ccaaaggcca catccgtcga tgtccctaaa caacagaggg atagaccacc
241 acggactgtt gccgaagttc aacaaaattt gcgttggact gagagaccac aagaccagaa
301 tgttaagacg tgggatgagc ttgaccacac aacaaaacaa cagatacttg atgaacacgc
361 tgagtggttt gatgccggtg gcttaggtcc aagtacacta cccactagtc atgaacggta
421 cacacatgag aatgatgaag gccaccaggt aaagtggtcg gctagggaag gtgtagacct
481 tggcatatcc gggctcacga cggtgtctgg gcctgagtgg aatatgtgcc cgctaccacc
541 agttgaccaa aggagcacga cacctgcaac tgagcccaca attggtgaca tgatcgaatt
601 ctatgaaggg cacatctatc attatgctat atacataggt caaggcaaga cggtgggtgt
661 acactcccct caagcagcct tctcaataac gaggatcacc atacagccca tatcagcttg
721 gtggcgagtc tgttatgtcc cacaaccaaa acagaggctc acatacgacc aactcaaaga
781 attagaaaat gaaccatggc cgtatgccgc agtcacgaac aactgcttcg aattttgttg
841 ccaggtcatg tgcttggaag atacttggtt gcaaaggaag ctcatctcct ctggccggtt
901 ttaccacccg acccaagatt ggtcccgaga cactccagaa ttccaacaag acagcaagtt
961 agagatggtt agggatgcag tgctagccgc tataaatggg ttggtgtcgc ggccatttaa
1021 agatcttctg ggtaagctca aacccttgaa cgtgcttaac ttactttcaa actgtgattg
1081 gacgttcatg ggggtcgtgg agatggtggt cctcctttta gaactctttg gaatcttttg
1141 gaacccacct gatgtttcca actttatagc ttcactcctg ccagatttcc atctacaggg
1201 ccccgaggac cttgccaggg atctcgtgcc aatagtattg ggggggatcg gcttagccat
1261 aggattcacc agagacaagg taagtaagat gatgaagaat gctgttgatg gacttcgtgc
1321 ggcaacccag ctcggtcaat atggcctaga aatattctca ttactaaaga agtacttctt
1381 cggtggtgat caaacagaga aaaccctaaa agatattgag tcagcagtta tagatatgga
1441 agtactatca tctacatcag tgactcagct cgtgagggac aaacagtctg cacgggctta
1501 tatggccatc ttagataatg aagaagaaaa ggcaaggaaa ttatctgtca ggaatgccga
1561 cccacacgta gtatcctcta ccaatgctct catatcccgg atctcaatgg ctagggctgc
1621 attggccaag gctcaagctg aaatgaccag caggatgcgt cctgtggtca ttatgatgtg
1681 tgggccccct ggtataggta aaaccaaggc agcagaacat ctggctaaac gcctagccaa
1741 tgagatacgg cctggtggta aggttgggct ggtcccacgg gaggcagtgg atcattggga
1801 tggatatcac ggagaggaag tgatgctgtg ggacgactat ggaatgacaa agatacagga
1861 agactgtaat aaactgcaag ccatagccga ctcagccccc ctaacactca attgtgaccg
1921 aatagaaaac aagggaatgc aatttgtgtc tgatgctata gtcatcacca ccaatgctcc
1981 tggcccagcc ccagtggact ttgtcaacct cgggcctgtt tgccgaaggg tggacttcct
2041 tgtgtattgc acggcacctg aagttgaaca cacgaggaaa gtcagtcctg gggacacaac
2101 tgcactgaaa gactgcttca agcccgattt ctcacatcta aaaatggagt tggctcccca
2161 agggggcttt gataaccaag ggaatacccc gtttggtaag ggtgtgatga agcccaccac
2221 cataaacagg ctgttaatcc aggctgtagc cttgacgatg gagagacagg atgagttcca
2281 actccagggg cctacgtatg actttgatac tgacagagta gctgcgttca cgaggatggc
2341 ccgagccaac gggttgggtc tcatatccat ggcctcccta ggcaaaaagc tacgcagtgt
2401 caccactatt gaaggattaa agaatgctct atcaggctat aaaatatcaa aatgcagtat
2461 acaatggcag tcaagggtgt acattataga atcagatggt gccagtgtac aaatcaaaga
2521 agacaagcaa gctttgaccc ctctgcagca gacaattaac acggcctcac ttgccatcac
2581 tcgactcaaa gcagctaggg ctgtggcata cgcttcatgt ttccagtccg ccataactac
2641 catactacaa atggcgggat ctgcgctcgt tattaatcga gcggtcaagc gtatgtttgg
2701 tacccgtaca gcagccatgg cattagaagg acctgggaaa gaacataatt gcagggtcca
2761 taaggctaag gaagctggaa aggggcccat aggtcatgat gacatggtag aaaggtttgg
2821 cctatgtgaa actgaagagg aggagagtga ggaccaaatt caaatggtac caagtgatgc
2881 cgtcccagaa ggaaagaaca aaggcaagac caaaaaggga cgtggtcgca aaaataacta
2941 taatgcattc tctcgccgtg gtctgagtga tgaagaatat gaagagtaca aaaagatcag
3001 agaagaaaag aatggcaatt atagtataca agaatacttg gaggaccgcc aacgatatga
3061 ggaagaatta gcagaggtac aggcaggtgg tgatggtggc ataggagaaa ctgaaatgga
3121 aatccgtcac agggtcttct ataaatccaa gagtaagaaa caccaacaag agcaacggcg
3181 acaacttggt ctagtgactg gatcagacat cagaaaacgt aagcccattg actggacccc
3241 gccaaagaat gaatgggcag atgatgacag agaggtggat tataatgaaa agatcaattt
3301 tgaagctccc ccgacactat ggagccgagt cacaaagttt ggatcaggat ggggcttttg
3361 ggtcagcccg acagtgttca tcacaaccac acatgtagtg ccaactggtg tgaaagaatt
3421 ctttggtgag cccctatcta gtatagcaat ccaccaagca ggtgagttca cacaattcag
3481 gttctcaaag aaaatgcgcc ctgacttgac aggtatggtc cttgaagaag gttgccctga
3541 agggacagtc tgctcagtcc taattaaacg ggattcgggt gaactacttc cgctagccgt
3601 ccgtatgggg gctattgcct ccatgaggat acagggtcgg cttgtccatg gccaatcagg
3661 gatgttactg acaggggcca atgcaaaggg gatggatctt ggcactatac caggagactg
3721 cggggcacca tacgtccaca agcgcgggaa tgactgggtt gtgtgtggag tccacgctgc
3781 agccacaaag tcaggcaaca ccgtggtctg cgctgtacag gctggagagg gcgaaaccgc
3841 actagaaggt ggagacaagg ggcattatgc cggccacgag attgtgaggt atggaagtgg
3901 cccagcactg tcaactaaaa caaaattctg gaggtcctcc ccagaaccac tgccccccgg
3961 agtatatgag ccagcatacc tggggggcaa ggacccccgt gtacagaatg gcccatccct
4021 acaacaggta ctacgtgacc aactgaaacc ctttgcggac ccccgcggcc gcatgcctga
4081 gcctggccta ctggaggctg cggttgagac tgtaacatcc atgttagaac agacaatgga
4141 taccccaagc ccgtggtctt acgctgatgc ctgccaatct cttgacaaaa ctactagttc
4201 ggggtaccct caccataaaa ggaagaatga tgattggaat ggcaccacct tcgttggaga
4261 gctcggtgag caagctgcac acgccaacaa tatgtatgag aatgctaaac atatgaaacc
4321 catttacact gcagccttaa aagatgaact agtcaagcca gaaaagattt atcaaaaagt
4381 caagaagcgt ctactatggg gcgccgatct cggaacagtg gtcagggccg cccgggcttt
4441 tggcccattt tgtgacgcta taaaatcaca tgtcatcaaa ttgccaataa aagttggcat
4501 gaacacaata gaagatggcc ccctcatcta tgctgagcat gctaaatata agaatcattt
4561 tgatgcagat tatacagcat gggactcaac acaaaataga caaattatga cagaatcctt
4621 ctccattatg tcgcgcctta cggcctcacc agaattggcc gaggttgtgg cccaagattt
4681 gctagcacca tctgagatgg atgtaggtga ttatgtcatc agggtcaaag aggggctgcc
4741 atctggattc ccatgtactt cccaggtgaa cagcataaat cactggataa ttactctctg
4801 tgcactgtct gaggccactg gtttatcacc tgatgtggtg caatccatgt catatttctc
4861 attttatggt gatgatgaga ttgtgtcaac tgacatagat tttgacccag cccgcctcac
4921 tcaaattctc aaggaatatg gcctcaaacc aacaaggcct gacaaaacag aaggaccaat
4981 acaagtgagg aaaaatgtgg atggactggt cttcttgcgg cgcaccattt cccgtgatgc
5041 ggcagggttc caaggcaggt tagatagggc ttcgattgaa cgccaaatct tctggacccg
5101 cgggcccaat cattcagatc catcagagac tctagtgcca cacactcaaa gaaaaataca
5161 gttgatttca cttctagggg aagcttcact ccatggtgag aaattttaca gaaagatttc
5221 cagcaaggtc atacatgaaa tcaagactgg tggattggaa atgtatgtcc caggatggca
5281 ggccatgttc cgctggatgc gcttccatga cctcggattg tggacaggag atcgcgatct
5341 tctgcccgaa ttcgtaaatg atgatggcgt ctaaggacgc tacatcaagc gtggatggcg
5401 ctagtggcgc tggtcagttg gtaccggagg ttaatgcttc tgaccctctt gcaatggatc
5461 ctgtagcagg ttcttcgaca gcagtcgcga ctgctggaca agttaatcct attgatccct
5521 ggataattaa taattttgtg caagcccccc aaggtgaatt tactatttcc ccaaataata
5581 cccccggtga tgttttgttt gatttgagtt tgggtcccca tcttaatcct ttcttgctcc
5641 atctatcaca aatgtataat ggttgggttg gtaacatgag agtcaggatt atgctagctg
5701 gtaatgcctt tactgcgggg aagataatag tttcctgcat accccctggt tttggttcac
5761 ataatcttac tatagcacaa gcaactctct ttccacatgt gattgctgat gttaggactc
5821 tagaccccat tgaggtgcct ttggaagatg ttaggaatgt tctctttcat aataatgata
5881 gaaatcaaca aaccatgcgc cttgtgtgca tgctgtacac ccccctccgc actggtggtg
5941 gtactggtga ttcttttgta gttgcagggc gagttatgac ttgccccagt cctgatttta
6001 atttcttgtt tttagtccct cctacggtgg agcagaaaac caggcccttc acactcccaa
6061 atctgccatt gagttctctg tctaactcac gtgcccctct cccaatcagt agtatgggca
6121 tttccccaga caatgtccag agtgtgcagt tccaaaatgg tcggtgtact ctggatggcc
6181 gcctggttgg caccacccca gtttcattgt cacatgttgc caagataaga gggacctcca
6241 atggcactgt aatcaacctt actgaattgg atggcacacc ctttcaccct tttgagggcc
6301 ctgcccccat tgggtttcca gacctcggtg gttgtgattg gcatatcaat atgacacagt
6361 ttggccattc tagccagacc cagtatgatg tagacaccac ccctgacact tttgtccccc
6421 atcttggttc aattcaggca aatggcattg gcagtggtaa ttatgttggt gttcttagct
6481 ggatttcccc cccatcacac ccgtctggct cccaagttga cctttggaag atccccaatt
6541 atgggtcaag tattacggag gcaacacatc tagccccttc tgtatacccc cctggtttcg
6601 gagaggtatt ggtctttttc atgtcaaaaa tgccaggtcc tggtgcttat aatttgccct
6661 gtctattacc acaagagtac atttcacatc ttgctagtga acaagcccct actgtaggtg
6721 aggctgccct gctccactat gttgaccctg ataccggtcg gaatcttggg gaattcaaag
6781 cataccctga tggtttcctc acttgtgtcc ccaatggggc tagctcgggt ccacaacagc
6841 tgccgatcaa tggggtcttt gtctttgttt catgggtgtc cagattttat caattaaagc
6901 ctgtgggaac tgccagctcg gcaagaggta ggcttggtct gcgccgataa tggcccaagc
6961 cataattggt gcaattgctg cttccacagc aggtagtgct ctgggagcgg gcatacaggt
7021 tggtggcgaa gcggccctcc aaagccaaag gtatcaacaa aatttgcaac tgcaagaaaa
7081 ttcttttaaa catgacaggg aaatgattgg gtatcaggtt gaagcttcaa atcaattatt
7141 ggctaaaaat ttggcaacta gatattcact cctccgtgct gggggtttga ccagtgctga
7201 tgcagcaaga tctgtggcag gagctccagt cacccgcatt gtagattgga atggcgtgag
7261 agtgtctgct cccgagtcct ctgctaccac attgagatcc ggtggcttca tgtcagttcc
7321 cataccattt gcctctaagc aaaaacaggt tcaatcatct ggtattagta atccaaatta
7381 ttccccttca tccatttctc gaaccactag ttgggtcgag tcacaaaact catcgagatt
7441 tggaaatctt tctccatacc acgcggaggc tctcaataca gtgtggttga ctccacccgg
7501 ttcaacagcc tcttctacac tgtcttctgt gccacgtggt tatttcaata cagacaggtt
7561 gccattattc gcaaataata ggcgatgatg ttgtaatatg aaatgtgggc atcatattca
7621 tttaattagg tttaattagg tttaatttga tgtt
//