Typing tool
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Typing tool
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Complete norovirus genomes
| MW305625 | GII.17 | |
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| GII.PNA6 |
ORF1: 1..5078
ORF2: 5059..6678
ORF3: 6678..7457
LOCUS MW305625 7511 bp RNA linear VRL 18-JUL-2024
DEFINITION Norovirus GII isolate Arg13099 nonstructural polyprotein (ORF1)
gene, partial cds; and VP1 (ORF2) and VP2 (ORF3) genes, complete
cds.
ACCESSION MW305625
VERSION MW305625.1
KEYWORDS .
SOURCE Norovirus GII
ORGANISM Norovirus GII
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norovirus norwalkense.
REFERENCE 1 (bases 1 to 7511)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A.U.A., Ford-Siltz,L.A., Green,K.Y.,
Galeano,M.E., Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N.,
Ushijima,H. and Parra,G.I.
TITLE Genome-wide analyses of human noroviruses provide insights on
evolutionary dynamics and evidence of coexisting viral populations
evolving under recombination constraints
JOURNAL PLoS Pathog 17 (7), e1009744 (2021)
PUBMED 34255807
REFERENCE 2 (bases 1 to 7511)
AUTHORS Tohma,K., Lepore,C.J., Martinez,M., Degiuseppe,J.I., Khamrin,P.,
Saito,M., Mayta,H., Nwaba,A., Ford-Siltz,L.A., Galeano,M.E.,
Zimic,M., Stupka,J.A., Gilman,R.H., Maneekarn,N., Ushijima,H.,
Green,K.Y. and Parra,G.I.
TITLE Direct Submission
JOURNAL Submitted (23-NOV-2020) CBER/OVRR/DVP/LHV, U.S. Food and Drug
Administration, 10903 New Hampshire Avenue, Silver Spring, MD
20993, USA
COMMENT ##Assembly-Data-START##
Assembly Method :: High-performance Integrated Virtual
Environment (HIVE) v. 2
Sequencing Technology :: Illumina
##Assembly-Data-END##
FEATURES Location/Qualifiers
source 1..7511
/organism="Norovirus GII"
/mol_type="genomic RNA"
/isolate="Arg13099"
/isolation_source="feces"
/host="Homo sapiens"
/db_xref="taxon:122929"
/geo_loc_name="Argentina"
/collection_date="2015"
/note="genotype: GII.17[GII.PNA]"
gene <1..5078
/gene="ORF1"
CDS <1..5078
/gene="ORF1"
/codon_start=3
/product="nonstructural polyprotein"
/protein_id="QPJ59211.1"
/translation="AAGRNNNSDNAKSSSDSLFSNMTVTFKKALGARPKQPPPGEIKQ
TNKPPRPPTPELVKRIPPPPPNGEDEPTVTYRAGEGVSGLPDLTTVRQPDAQNTAYSV
PPLSQREAGEAREPLPGSILEMWDGEIYHYGLYVDRGNVLGVHKPPAAISLAKIELTP
LSLYWRVVYTPQYLMSPDTLKNLNGESFPYTAFDNNCYAFCCWVLDLNDSWLSRRMIQ
RTTGFFRPYQEWNKKPLPTMDEPKIKKVANALLCALSSLFTRPIKDIIGKLRPLNILN
ILATCDWTFAGIVESLILLAELFGVFWTPPDVSAMIAPLLGDYEMQGPEDLAVELVPV
VMGGIGLVLGFTKEKIGKMLSSAASTLRACKDLGAYGLEILKLVMKWFFPKKEEADEL
AMVRAIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEAKARKLSTKSASPDIV
GTINALLARIAAARSLVHKAKEELSSRQRPVVVMLSGRPGIGKTHLARELAKKIATTL
AGDQRVGLVPRNGVDHWDAYKGERVVLWDDYGMSNPITDALRLQELADTCPLTLNCDR
IENKGKVFDSDAIIITTNLANPAPLDYVNFEACSRRIDFLVYADAPDIEKAKRDFPGQ
PDMWKEHYRPDFSHIKLQLAPQGGFDKNGNTPHGKGVMKSLTVGSLIARASGLLHERM
DEFEFQGPSLTTFNFDRNKVAAFRQLAAENKYGMMDTLRVGNQLKSVKTMDELKRAIR
NVTIRKCQIVYNGCTYTIESDGRGKVSVDKVQSATVQTNNELVGALHHLRSARIRYYV
KCFQEAVYSILQIAGAAFVTSRIVRRMNISSLWSKPPVEEDDETEDKDGCPKPREEDE
IIIVSKDIKEEGKKGKNKTGRGKKHTAFSSKGLSDEEYDEYKRIREERNGKYSIEEYL
QDRDRYYEELAIARATDEDFCEEEEVKIRQRIFRPTRKQRKEERATLGLVTGSEIRKR
NPDDFKPKGKLWADDNRSVDYNERIDFEAPPSIWSRIVSFGSGWGFWVSPSLFITSTH
VIPKGITEAFGVPISQIQIHKSGEFCRLRFPKPIRTDVSGMILEEGAPEGTVATILVK
RPTGELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYK
RGNDFVVIGVHTAAARGGNTVICATQGGEGEATLEGGDNKGTYCGAPILGPGNAPKLS
TKTKFWRSSNAPLPPGTYEPAYLGGRDPRVKGGPSLQQVMRDQLKPFTEPRGKQPNPK
VLEAAKQTIINVLEQTIDPPQKWTYAQACASLDKTTSSGHPYHVRKNDYWSGESFTGK
LADQASKANLMYEEGKHMPPVFTAALKDELVKTDKIYGKIKKRLLWGSDLSTMIRCAR
AFGGLMDELKAHCVTLPVRVGMNMNEDGPIIFEKHSRYKYHYDADYSRWDSTQQRAVL
ASALEIMVRFSAEPQLAQIVAEDLLAPSVVDVGDFKIAINEGLPSGVPCTSQWNSISH
WLLTLCALSEVTGLGPDIIQANSMYSFYGDDEIVSTDIKLDPEKLTAKLKEYGLKPTR
PDKTEGPLVISEDLNGLTFLRRTVTRDPAGWFGKLDQSSILRQIYWTRGPNHEDPSET
MIPHAQRPVQLMALLGESSLHGPSFYSKISKLVISELKEGGMDFYVPRQESMFRWMRF
SDLSTWEGDRNLAPSFVNEDGVE"
mat_peptide <1..968
/gene="ORF1"
/product="p48"
mat_peptide 969..2066
/gene="ORF1"
/product="NTPase"
mat_peptide 2067..2603
/gene="ORF1"
/product="p22"
mat_peptide 2604..3002
/gene="ORF1"
/product="VPg"
mat_peptide 3003..3545
/gene="ORF1"
/product="Pro"
mat_peptide 3546..5075
/gene="ORF1"
/product="RdRp"
gene 5059..6678
/gene="ORF2"
CDS 5059..6678
/gene="ORF2"
/note="major capsid protein"
/codon_start=1
/product="VP1"
/protein_id="QPJ59212.1"
/translation="MKMASNDAAPSNDGAAGLVPEGNNETLPLEPVAGAAIAAPVTGQ
NNIIDPWIRLNFVQAPNGEFTVSPRNSPGEILLNLELGPDLNPYLAHLSRMYNGYAGG
VEVQVLLAGNAFTAGKILFAAVPPNFPVEFLSPAQITMLPHLIVDVRTLEPIMIPLPD
IRNTFFHYNNQPANRMRLVAMLYTPLRSNGSGDDVFTVSCRVLTRPTPDFEFTYLVPP
SVESKTKPFSLPILTLSELTNSRFPVPIDSLFTAQNNVLQVQCQNGRCTLDGELQGTT
QLLPAGICAFRGRVTARTDHPDKWHMQLQNLNGTTYDPTDDVPAPLGTPDFKGLLFGV
ASQRNVGGSTPGATRAHEVVISTTSSQFVPKLGSVNFGSTSDDFDEGQPTKFTPVGIK
VEQNHTFRQWELPDYSGRLTLNMNLAPPVAPNFPGEQLLFFRSNVPCAGGYDPGIIDC
LIPQEWIQHFYQESAPSQSDVALIRYVNPDTGRTLFEAKLHRTGYITVAHSGDYPLVV
PANGYFRFDSWVNQFYSLAPMGTGNGRRRAQ"
gene 6678..7457
/gene="ORF3"
CDS 6678..7457
/gene="ORF3"
/note="minor structural protein; small basic protein"
/codon_start=1
/product="VP2"
/protein_id="QPJ59213.1"
/translation="MAGAFIAGLAGDMLTSTVGSLATAGANAINQKIDFENNKQLQSA
SFQHDKEMLQSQVQATKQLQADMISIKQGILTAGGFSPTDAARGAINAPMTKVLDWSG
TRYWAPNSTRTTSYSGQFTSSPVHRPSPTVPQPKAVKSKSSAYSSSSGSVYSLSTQST
MLPSDSSNSLVSSASTKMTNLSGSSRDRTAEWVNQQRSLSPFMSGALNISHVTPPSSR
ASSSGTVSTVPKEVLDSWTSAFNTRRQPLFAHLRVRGESRV"
ORIGIN
1 ccgctgctgg cagaaacaac aacagcgaca atgcgaaatc ttcaagtgat agtttatttt
61 ctaacatgac tgtcactttt aagaaagccc tcggggcgcg gcctaaacaa ccgcccccgg
121 gagaaataaa acaaacaaac aaaccaccaa gaccaccgac accggaattg gtgaagagaa
181 tacctccacc cccacctaat ggcgaggacg aaccaacggt tacttatagg gcgggggaag
241 gcgtgtcagg actgcctgac ttaacaactg tcagacaacc tgatgcgcaa aacacagcct
301 acagtgtccc cccactcagc cagagagaag ctggagaagc cagagaaccg ttacctggtt
361 ctatcttgga aatgtgggac ggtgagatct accactatgg gctgtatgtg gatcgtggca
421 acgtactcgg ggttcacaaa ccgcctgctg caataagcct cgccaaaatt gaattaacac
481 ctttatcact ctactggagg gtggtttaca ctcctcagta tttgatgtca ccagacacat
541 tgaagaacct aaatggagaa tcattcccct acacagcatt tgacaacaac tgctacgcat
601 tttgttgctg ggtcttggac ctcaatgact cgtggcttag caggagaatg attcaaagga
661 ccactgggtt ctttaggcct taccaagagt ggaacaaaaa gcccctgcca accatggatg
721 agcccaaaat caagaaagtc gcaaacgccc ttctttgcgc actctcctca ctcttcacga
781 ggcccattaa agacatcatt ggaaaactca gaccacttaa tatcctcaac atactggcta
841 cctgtgattg gaccttcgca ggcattgtgg aatccttgat tcttctagct gaactctttg
901 gagtgttttg gacaccccca gatgtgtctg ctatgattgc tcccttactc ggtgactacg
961 agatgcaagg ccctgaagat ctggccgttg aactcgtgcc cgtagtaatg gggggaatag
1021 gtttggtgct cggattcacc aaggaaaaga tcggcaagat gctgtcatca gctgcttcca
1081 cactcagggc ctgcaaagac ttaggtgcat atggattgga aatactcaaa ctagtcatga
1141 aatggttctt cccaaagaaa gaagaggcag atgaacttgc catggtgagg gctatagagg
1201 atgctgtatt ggatttggag gcaatagaaa acaaccacat gaccactctt ctcaaagaca
1261 aggacagctt agcaacatac atgagaaccc tcgacctgga ggaagcaaaa gcaagaaaac
1321 tctctactaa gtctgcctca cctgatatcg tgggcacaat aaacgccctc ttggcaagaa
1381 ttgcggctgc tagatcacta gttcacaaag caaaggagga actgtcgagc agacaaaggc
1441 ctgttgttgt gatgttatct ggtaggccag gtataggaaa gacccacctt gcaagggagc
1501 tggccaagaa aattgccaca acattagcag gtgaccaaag ggtggggcta gtgcccagaa
1561 acggggtaga ccactgggat gcttacaaag gagaaagagt ggtgctatgg gacgattatg
1621 gtatgagcaa tccaataaca gatgctctaa gactccaaga gttggccgac acttgcccat
1681 taaccctaaa ttgtgacaga attgagaaca aagggaaagt gtttgatagt gatgccataa
1741 tcataacaac caaccttgca aaccctgcac cgctagacta cgtcaacttt gaggcctgct
1801 ccagacgcat agacttccta gtgtatgcag atgctccaga catcgaaaag gccaaacgtg
1861 acttccccgg gcagccagat atgtggaaag aacactatag accagacttc tcacacatca
1921 aactccagct tgcaccacaa ggaggttttg ataagaatgg caacacacct catggaaagg
1981 gtgtgatgaa gtccctgacg gttggttcgc taatcgccag ggcatctgga ctgctccatg
2041 aaagaatgga tgagtttgaa ttccaaggcc ccagcctaac aactttcaat tttgaccgta
2101 acaaggtcgc tgccttcagg caactggcag ctgagaacaa atatggcatg atggacaccc
2161 taagagttgg taatcaacta aagagtgtta aaaccatgga tgaacttaag cgggccatta
2221 ggaacgtcac catcagaaag tgccagatag tgtacaatgg gtgcacctac accattgagt
2281 ctgatgggcg cggcaaagtg tcagtcgaca aggtgcagag tgcaacggtc cagacaaaca
2341 atgaacttgt gggagcacta caccatctca ggtctgcaag aataaggtac tatgtcaagt
2401 gcttccagga ggcagtctat tccatactac aaattgccgg tgcggccttt gtcacctcac
2461 gaattgtgag gcgcatgaac atttcaagcc tttggtccaa accacctgtt gaggaagatg
2521 atgaaactga ggacaaagat ggatgcccca aacccagaga agaggatgaa atcataatcg
2581 tctctaagga catcaaagaa gaggggaaga agggcaaaaa caaaaccggc cgtggtaaga
2641 aacacacggc tttctccagc aaaggcctca gtgatgagga gtatgatgag tacaagagga
2701 tcagagaaga aaggaatgga aaatactcaa tagaggagta ccttcaagac agggacaggt
2761 actatgaaga gcttgccatt gccagagcca ctgatgaaga cttctgtgag gaggaagagg
2821 tgaagattcg tcaaagaatt ttccgcccta ccagaaaaca acggaaggag gagagagcca
2881 cacttgggct cgtcacaggg tcagagatca gaaagaggaa cccagatgac ttcaaaccaa
2941 aaggaaaatt gtgggctgac gacaaccgga gtgtggacta caatgaaaga atagactttg
3001 aagcaccacc aagtatctgg tctagaatag tcagttttgg ttcaggttgg ggattctggg
3061 tgtctccaag cctcttcata acatcaacac atgtgatacc aaaaggcatc acggaggcat
3121 ttggggtacc aattagccag attcaaattc acaaatcagg agaattttgc cgccttcgat
3181 ttcccaaacc aatcagaaca gatgtgagtg gaatgatctt ggaagaaggt gctcctgaag
3241 ggactgttgc gaccattctt gtgaaacggc caactggaga gctaatgccc cttgcagcca
3301 gaatgggaac ccatgctaca atgaaaattc agggaagaac agttggtggc caaatgggca
3361 tgctattaac aggctcaaat gccaaaagca tggatcttgg aacaacacca ggtgattgtg
3421 gttgtcccta catatacaaa agaggcaatg acttcgtagt cattggcgtg cacactgcag
3481 cagcacgcgg gggcaacacc gtcatctgtg ccacacaagg aggtgagggt gaggccactc
3541 ttgaaggggg tgacaacaag ggaacctact gtggagcccc cattctgggg cctggcaatg
3601 caccaaaatt gagcacaaag acaaaatttt ggaggtcatc caacgcacca ctcccaccag
3661 gtacctatga accagcttac ctgggtggta gggacccccg tgtgaaagga ggcccttcat
3721 tacaacaggt catgagagat caattgaagc ccttcactga gcccagggga aaacagccaa
3781 acccaaaagt ccttgaagca gcaaaacaaa ctataatcaa tgtacttgag cagaccatag
3841 acccccctca aaaatggacc tatgcccaag cttgtgcctc gcttgacaag acaacatcta
3901 gtggtcatcc ctatcacgtt cgcaagaacg actactggag tggtgagtct ttcacaggaa
3961 aattggcaga tcaagcatca aaagcaaatc tcatgtacga ggagggaaaa cacatgccac
4021 cagtgtttac tgcagcactc aaggatgaac tggttaaaac tgacaagatc tatgggaaaa
4081 ttaagaagag gctcttgtgg ggttcagacc tttccaccat gatacggtgt gccagggcat
4141 ttggcggcct aatggatgag ctcaaagcgc actgtgtgac cctccctgta agagtaggaa
4201 tgaatatgaa tgaagatggt cccataatct ttgagaaaca ttccaggtat aaatatcatt
4261 atgatgctga ttactcccgt tgggactcca cacagcaacg ggcagtgcta gcatcagcac
4321 ttgaaatcat ggtgaggttt tctgcagaac cacaattggc acaaatagta gctgaggacc
4381 tgttggctcc aagtgtggtt gatgtgggtg atttcaaaat agcaatcaat gagggcctac
4441 cttctggtgt gccttgcacg tcgcagtgga attccatctc ccattggcta ctcacactgt
4501 gtgccttgtc tgaagtgaca ggcctaggcc ctgacatcat ccaggccaac tccatgtatt
4561 ccttctatgg tgatgatgag attgtaagca ctgatataaa acttgaccca gaaaagctaa
4621 ctgcaaaact caaggaatac ggcctcaagc ccacccgccc tgacaaaacc gaggggccat
4681 tggtgattag tgaagacctg aatggactga ctttcctccg acggacagta acccgtgacc
4741 cagcaggctg gtttgggaaa ctggaccaaa gctccatcct caggcaaatc tactggacta
4801 gaggacccaa tcatgaagat cccagtgaaa ccatgatacc acatgcacaa agacccgtcc
4861 agcttatggc actgcttggg gaatcatccc tacatggacc atcattctat agcaaaatta
4921 gcaaattagt tatatctgaa cttaaagaag ggggaatgga tttttatgtg cccagacaag
4981 agtcaatgtt cagatggatg aggttctcag atctgagcac atgggagggc gatcgcaatc
5041 tggctcccag ttttgtgaat gaagatggcg tcgaatgacg ctgctccatc taacgatggt
5101 gctgctggtc tcgtaccaga gggcaacaac gagacccttc ccttggaacc agttgcaggc
5161 gcagctattg ccgcacctgt cactggtcaa aacaatataa ttgacccctg gattagatta
5221 aattttgtac aagcaccaaa tggagagttc acagtgtcac ctaggaactc tcctggagaa
5281 atcttactaa atttggaatt aggacctgat ctgaacccat atttggctca tctttcaaga
5341 atgtataatg gctatgctgg tggtgtagag gtgcaagttc tcctagcggg gaatgcgttc
5401 accgctggaa agattctgtt cgccgccgtg ccaccaaatt ttccagtaga attcctaagt
5461 ccagctcaaa ttacaatgct cccacattta atagttgatg ttaggaccct tgaaccaatt
5521 atgattcccc ttcccgatat taggaatacc ttctttcatt ataacaatca acctgcaaac
5581 cgtatgagat tagttgctat gctttatact ccacttagat ctaatggctc aggtgatgat
5641 gtgtttactg tttcttgcag ggttttgact aggcctactc ctgattttga atttacttat
5701 ttggttcccc cgtctgtaga gtcaaagact aagcctttct cattgcctat cctaacgctt
5761 tctgaattaa caaattccag attcccagtc cctattgatt cactctttac tgctcagaac
5821 aatgtgctgc aggtgcagtg ccaaaatggt aggtgtacgc ttgatggtga gctacaaggc
5881 acaacccaat tactgccagc agggatttgt gcattcagag gacgggtgac agcacgaacc
5941 gaccaccctg ataagtggca catgcagctg caaaacctca atggcactac atatgaccca
6001 actgatgatg tgccagcccc acttggcaca cccgacttca aaggtcttct ctttggagtt
6061 gcaagtcaga gaaatgtggg tggcagcaca ccaggtgcca ccagagcaca tgaggtagtc
6121 atctcaacaa ctagttccca atttgtcccc aaattaggtt cagtcaattt tggaagcacc
6181 agtgatgatt ttgacgaagg tcaaccaaca aaattcacac ctgtgggcat taaagtagaa
6241 caaaaccaca ctttcagaca atgggagctg ccagactact caggacggct cactctaaat
6301 atgaaccttg cacccccagt tgcaccaaac tttcccggtg agcagctgct gttcttcaga
6361 tccaatgtcc catgcgccgg aggatatgac cctggcatca ttgattgtct tattccacag
6421 gaatggatcc aacacttcta tcaggaatca gctccctctc agtcagatgt ggccctaatc
6481 aggtatgtca accctgacac aggtcgcact ttgtttgagg caaaattgca caggactgga
6541 tacattactg ttgctcactc tggggactat ccccttgttg ttccggccaa tggatacttt
6601 agatttgatt cttgggtaaa tcaattttac tcactcgccc ccatgggaac tgggaatggg
6661 cgtaggagag ctcaataatg gctggagcct tcatagcagg attggcaggc gacatgctca
6721 cgtcaacagt gggctccctg gcgaccgccg gggcaaacgc catcaaccaa aagatagact
6781 ttgagaataa caaacagctc cagtccgcct ccttccaaca tgataaagag atgctccaat
6841 cacaggtgca ggcaaccaaa cagctgcagg ctgatatgat atccataaaa caggggattc
6901 tgaccgcagg cggcttttcc cctactgatg cagcaagagg ggccatcaac gcacccatga
6961 caaaggtgct tgactggtct ggaacccgtt actgggcgcc caactccaca aggaccacca
7021 gttattccgg gcaattcacc tcctcacctg tgcatcgtcc cagcccgact gttcctcaac
7081 caaaagctgt gaaatccaaa tcatctgcat attcttcttc ttctggtagt gtttatagtt
7141 tgtctaccca atcaacaatg ttaccatcag attcttctaa tagtttagtt tcttctgctt
7201 caacaaaaat gacaaatttg agtggctctt ctagagatag gacagcagag tgggtcaacc
7261 aacagaggag cctcagccca ttcatgagtg gtgcacttaa catctcacat gtgacaccgc
7321 cttcaagcag ggcttccagt tctgggacag tctcaaccgt gcccaaagag gttttggact
7381 cctggacatc tgcattcaac acacgcagac agccgctctt cgcacacctc agagtgaggg
7441 gggagtcacg tgtttagtga aaagaatcaa ttggatttaa aattttaaaa tttggcctat
7501 ttgaatcttt t
//